Mitsunobu Reaction

The Mitsunobu reaction performs a stereospecific conversion of an alcohol to a primary amine with inversion of configuration. The alcohol is treated with triphenylphosphane, diethyl azodicarboxylate (DEAD) and, usually, phthalimide, followed by hydrazinolysis.


[1] Mitsunobu, O.; Wada, M.; Sano, T. J. Am. Chem. Soc. 1972, 94, 679.
[2] Hughes, D. L. Org. Reac. 1992, 42, 335-656. (Review: "The Mitsunobu Reaction")


Reaktionsschema: ROH → RNHH

Reaktionscode: -ROH+RNHH

Burkhard Kirste, 1994/12/16